About this calculator
This calculator estimates transferrin saturation (TSAT) from serum iron and TIBC. TSAT is commonly reviewed with ferritin, CBC results, and clinical context when evaluating possible iron deficiency or iron overload.
TSAT can vary by timing, inflammation, liver disease, pregnancy, recent iron therapy, and lab method. This tool does not diagnose anemia or hemochromatosis.
Transferrin saturation can be calculated using serum iron and total iron-binding capacity (TIBC): TSAT (%) = serum iron ÷ TIBC × 100. Interpretation requires ferritin, CBC, inflammation context, and clinician judgment.
Activated — serum iron/TIBC formula
Educational estimate only; not a diagnosis, prescription, or treatment plan.
Formula and method
Transferrin saturation (%) = serum iron ÷ total iron-binding capacity × 100. Enter serum iron and TIBC in the same conventional units, usually µg/dL.
Limitations and when not to rely on this result
- Educational estimate only; not a diagnosis, prescription, or treatment plan.
- Result depends on accurate inputs and may not apply to complex medical situations.
- Use clinician judgment, local guidance, and urgent care pathways when symptoms are severe.
Frequently asked questions
What does transferrin saturation measure? +
It estimates the percentage of iron-binding capacity that is occupied by iron.
What formula does this calculator use? +
TSAT percentage equals serum iron divided by TIBC, multiplied by 100.
Does low TSAT prove iron deficiency? +
No. Low TSAT can support iron deficiency, but interpretation also depends on ferritin, CBC results, inflammation, and clinical context.
Does high TSAT prove iron overload? +
No. A high value should be interpreted with ferritin, liver tests, repeat fasting studies when appropriate, and clinician assessment.
Can I use transferrin instead of TIBC? +
This version uses serum iron and TIBC only to keep the formula transparent. Use a lab-reported TSAT when your report provides it directly.